Inherited Disease Working Group of the Japan Society for Hematopoietic Cell Transplantation. Comparison of second transplantation and donor lymphocyte infusion for donor mixed chimerism after allogeneic stem cell transplantation for nonmalignant diseases.

In this study from Inherited Disease Working Group of the Japan Society for Hematopoietic Cell Transplantation, the outcomes of 49 patients who had mixed chimerism after hematopoietic stem cell transplantation (HSCT) who either undewent fonor lymphocyte infusion /DLI; n=36) or a second HSCT (n=13) were summarized. Among patients undergoing DLI, the rates of successful response were significantly higher in patients having at least 30% donor chimerism (94.1%) than in patients having less than 30% donor chimerism (61.1%; p = 0.041). Authors concluded that, DLI yielded promising response rates in most patients with higher donor chimerism levels, whereas second HSCT was more likely to benefit for patients with lower donor chimerism levels.

This summary is prepared by Sule Unal,M.D.

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