Randomized study of reduced-intensity chemotherapy combined with imatinib in adults with Ph-positive acute lymphoblastic leukemia.

Chalandon Y, Thomas X, Hayette S, et al.  Blood, 125:3 711,  Jun 2015

Randomized study showed that reduced-intensity chemotherapy combined with imatinib is associated with lower early mortality and higher CR rate compared to a standard chemotherapy-imatinib combination protocol in adults with Ph-positive acute lymphoblastic leukemia.